Clc genomics workbench mapping protocol9/20/2023 ![]() ![]() Northstar Select is an 81-gene pan-cancer somatic mutation profiling panel and Northstar Response is a methylation-based, tissue-agnostic treatment response monitoring assay. The Saphyr Chip G3.3, a new version of the instrument control software (ICS v5.3), and a new version of Bionano Access enable improved throughput and success rates when two Saphyr Chips are loaded in parallel, allowing three to six more samples to be processed per workweek, the company said.īillionToOne launched its Northstar Response and Northstar Select liquid biopsy assays for commercial use in patients with late-stage solid tumors. The Bionano Prep Direct Label and Stain-G2 (DLS-G2) kit offers increased reagent stability and labeling efficiency, according to the company, resulting in a significantly faster sample-to-results workflow. The Bionano Prep SP-G2 kit offers higher gDNA quality, improved ease of use, and increased DNA throughput. According to Bionano, the reports from OGM-Dx HemeOne will include a targeted analysis of guidelines-based, disease-specific SVs, and a whole-genome analysis for the detection of recurrent and novel biomarkers associated with various hematological malignancy indications.īionano Genomics Sample Prep Kits, Chips, and Instrument Softwareīionano Genomics has launched new versions of its sample prep kits, chips, and instrument software. The assay analyzes blood or bone marrow samples to detect structural variants (SVs) of diagnostic and prognostic utility in individuals with a new or an existing diagnosis of a hematological malignancy. According to Thermo Fisher, the kit obtained its CE-IVD mark in May 2022.īionano Laboratories, a subsidiary of Bionano Genomics, has launched OGM-Dx HemeOne, a laboratory-developed test based on optical genome mapping (OGM). The assay works with HIV RNA extracted from plasma or dried blood spots and is designed to detect genomic mutations in the protease, reverse transcriptase, and integrase regions of the HIV-1 pol gene across nine subtypes of global significance. Based on Sanger sequencing, the test examines positive HIV samples to identify genetic variants that may resist common antiretroviral therapeutics. Thermo Fisher Scientific has launched the CE-IVD-marked Applied Biosystems TaqPath Seq HIV-1 Genotyping Kit. Thermo Fisher Scientific Applied Biosystems TaqPath Seq HIV-1 Genotyping Kit Qiagen is touting CLC Genomics Workbench Premium as "ideal" for neonatal screening for hereditary diseases or population genomics studies. The company said that this technology will allow laboratories to process a genome sequenced at 34X depth in 25 minutes for $1 of cloud computing costs and a 50X exome in 90 seconds for a few pennies on "standard" clouds. Qiagen Digital Insights has released an update to its Qiagen CLC Genomics Workbench Premium, incorporating a software accelerator called LightSpeed for faster analysis of next-generation sequencing data. Advances in Clinical Genomics Profiling.Although several groups are trying to tackle this, there is to our knowledge no good bioinformatic solution. However, the main problem in metagenome assembly is the presence of multiple closely realted strains, which acts like poison to the assemblers. If CLC is not an option (It’s quite expensive) we recommend to take a look at khmer which also tries to enable assembly of large metagenome datasets. We use standard settings except a kmer of 63. We have sucessfully assembled metagenome datasets >300 Gbp in less than a day on server with 40 processers and 256 Gbp of RAM. ![]() We are currently using CLC’s de novo assembly implementation as it is able to handle a wide range of coverage abundances, is memory friendly and fast. Remove Illumina nextera adapters if foundĭe novo assembly of metagenomes is a field in constant development and numerous strategies exists. ![]()
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